The C-terminus of H-Ras as a target for the covalent binding of reactive compounds modulating Ras-dependent pathways.

The C-terminus of H-Ras as a target for the covalent binding of reactive compounds modulating Ras-dependent pathways.

Ras proteins are crucial players in differentiation and oncogenesis and constitute important drug targets. The localization and activity of Ras proteins are highly dependent on posttranslational modifications at their C-termini. In addition to an isoprenylated cysteine, H-Ras, but not other Ras prot...

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Bibliographic Details
Main Authors: Clara L Oeste, Beatriz Díez-Dacal, Francesca Bray, Mario García de Lacoba, Beatriz G de la Torre, David Andreu, Antonio J Ruiz-Sánchez, Ezequiel Pérez-Inestrosa, Carlota A García-Domínguez, José M Rojas, Dolores Pérez-Sala
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3017061?pdf=render

Internet

http://europepmc.org/articles/PMC3017061?pdf=render

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