Design of Fluorescent Coumarin-Hydroxamic Acid Derivatives as Inhibitors of HDACs: Synthesis, Anti-Proliferative Evaluation and Docking Studies

Design of Fluorescent Coumarin-Hydroxamic Acid Derivatives as Inhibitors of HDACs: Synthesis, Anti-Proliferative Evaluation and Docking Studies

Coumarin-hydroxamic acid derivatives <b>7a</b>–<b>k</b> were herein designed with a dual purpose: as antiproliferative agents and fluorescent probes. The compounds were synthesized in moderate yields (30–87%) through a simple methodology, biological evaluation was carried out...

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Bibliographic Details
Main Authors: Santiago García, Itzel Mercado-Sánchez, Luis Bahena, Yolanda Alcaraz, Marco A. García-Revilla, Juvencio Robles, Nancy Santos-Martínez, David Ordaz-Rosado, Rocío García-Becerra, Miguel A. Vazquez
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Molecules
Subjects:
coumarins
hydroxamic acids
HDAC
gene expression
fluorescent probe
docking analysis
Online Access:https://www.mdpi.com/1420-3049/25/21/5134

Internet

https://www.mdpi.com/1420-3049/25/21/5134

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