Extracellular matrix stiffness controls cardiac valve myofibroblast activation through epigenetic remodeling

Extracellular matrix stiffness controls cardiac valve myofibroblast activation through epigenetic remodeling

Abstract Aortic valve stenosis (AVS) is a progressive fibrotic disease that is caused by thickening and stiffening of valve leaflets. At the cellular level, quiescent valve interstitial cells (qVICs) activate to myofibroblasts (aVICs) that persist within the valve tissue. Given the persistence of my...

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Bibliographic Details
Main Authors: Cierra J. Walker, Dilara Batan, Carrie T. Bishop, Daniel Ramirez, Brian A. Aguado, Megan E. Schroeder, Claudia Crocini, Jessica Schwisow, Karen Moulton, Laura Macdougall, Robert M. Weiss, Mary A. Allen, Robin Dowell, Leslie A. Leinwand, Kristi S. Anseth
Format: Article
Language:English
Published: Wiley 2022-09-01
Series:Bioengineering & Translational Medicine
Subjects:
ATAC‐Seq
epigenetics
hydrogels
myofibroblasts
RNA‐Seq
valve interstitial cells
Online Access:https://doi.org/10.1002/btm2.10394

Internet

https://doi.org/10.1002/btm2.10394

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