Expansion of granulocyte-macrophage colony-stimulating factor producing CD4+ T cells in an animal model with enhanced interleukin-1 signal

Expansion of granulocyte-macrophage colony-stimulating factor producing CD4+ T cells in an animal model with enhanced interleukin-1 signal

Interleukin-1, a pro-inflammatory cytokine, plays a crucial role in inflammatory disease pathogenesis. Interleukin-1 receptor antagonist knockout (IL-1Ra KO) mice spontaneously develop aortitis, arthritis and dermatitis, and are employed as a model for human inflammatory diseases. Previous studies h...

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Bibliographic Details
Main Authors: Sho Ishigaki, Keiko Yoshimoto, Mitsuhiro Akiyama, Kotaro Matsumoto, Katsuya Suzuki, Kazuhiro Yamanoi, Yoichiro Iwakura, Tsutomu Takeuchi, Yuko Kaneko
Format: Article
Language:English
Published: Taylor & Francis Group 2024-11-01
Series:Immunological Medicine
Subjects:
CD4+ T cells
GM-CSF
IL-1
inflammation
Online Access:https://www.tandfonline.com/doi/10.1080/25785826.2024.2430913

Internet

https://www.tandfonline.com/doi/10.1080/25785826.2024.2430913

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