Regulatory networks driving expression of genes critical for glioblastoma are controlled by the transcription factor c-Jun and the pre-existing epigenetic modifications

Regulatory networks driving expression of genes critical for glioblastoma are controlled by the transcription factor c-Jun and the pre-existing epigenetic modifications

Abstract Background Glioblastoma (GBM, WHO grade IV) is an aggressive, primary brain tumor. Despite extensive tumor resection followed by radio- and chemotherapy, life expectancy of GBM patients did not improve over decades. Several studies reported transcription deregulation in GBMs, but regulatory...

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Bibliographic Details
Main Authors: Adria-Jaume Roura, Paulina Szadkowska, Katarzyna Poleszak, Michal J. Dabrowski, Aleksandra Ellert-Miklaszewska, Kamil Wojnicki, Iwona A. Ciechomska, Karolina Stepniak, Bozena Kaminska, Bartosz Wojtas
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Clinical Epigenetics
Subjects:
Glioblastoma
Transcriptional deregulation
Transcription factors
Gene expression
Chromatin accessibility
DNA binding
Online Access:https://doi.org/10.1186/s13148-023-01446-4

Internet

https://doi.org/10.1186/s13148-023-01446-4

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