Hepatic PPARα function and lipid metabolic pathways are dysregulated in polymicrobial sepsis

Hepatic PPARα function and lipid metabolic pathways are dysregulated in polymicrobial sepsis

Abstract Despite intensive research and constant medical progress, sepsis remains one of the most urgent unmet medical needs of today. Most studies have been focused on the inflammatory component of the disease; however, recent advances support the notion that sepsis is accompanied by extensive meta...

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Bibliographic Details
Main Authors: Lise Van Wyngene, Tineke Vanderhaeghen, Steven Timmermans, Jolien Vandewalle, Kelly Van Looveren, Jolien Souffriau, Charlotte Wallaeys, Melanie Eggermont, Sam Ernst, Evelien Van Hamme, Amanda Gonçalves, Guy Eelen, Anneleen Remmerie, Charlotte L Scott, Caroline Rombouts, Lynn Vanhaecke, Liesbet De Bus, Johan Decruyenaere, Peter Carmeliet, Claude Libert
Format: Article
Language:English
Published: Springer Nature 2020-02-01
Series:EMBO Molecular Medicine
Subjects:
fibrates
lipid metabolism
lipotoxicity
liver
sepsis
Online Access:https://doi.org/10.15252/emmm.201911319

Internet

https://doi.org/10.15252/emmm.201911319

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