Targeting Kaposi’s sarcoma associated herpesvirus encoded protease (ORF17) by a lysophosphatidic acid molecule for treating KSHV associated diseases

Targeting Kaposi’s sarcoma associated herpesvirus encoded protease (ORF17) by a lysophosphatidic acid molecule for treating KSHV associated diseases

Kaposi’s sarcoma associated herpesvirus (KSHV) is causative agent of Kaposi’s sarcoma, Multicentric Castleman Disease and Pleural effusion lymphoma. KSHV-encoded ORF17 encodes a protease which cleaves -Ala-Ala-, -Ala-Ser- or -Ala-Thr-bonds. The protease plays an important role in assembly and matura...

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Bibliographic Details
Main Authors: Misbahuddin M Rafeeq, Alaa Hamed Habib, Alaa F. Nahhas, Najat Binothman, Majidah Aljadani, Jawaher Almulhim, Ziaullah M Sain, Mohammad Zubair Alam, Norah A Alturki, Qamre Alam, Manish Manish, Rajnish Kumar Singh
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
KSHV
protease
ORF17
reactivation
malignancies
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2023.1060156/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2023.1060156/full

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