Osteogenic Commitment of Human Periodontal Ligament Cells Is Predetermined by Methylation, Chromatin Accessibility and Expression of Key Transcription Factors

Osteogenic Commitment of Human Periodontal Ligament Cells Is Predetermined by Methylation, Chromatin Accessibility and Expression of Key Transcription Factors

Periodontal ligament stem cells (PDLCs) can be used as a valuable source in cell therapies to regenerate bone tissue. However, the potential therapeutic outcomes are unpredictable due to PDLCs’ heterogeneity regarding the capacity for osteoblast differentiation and mineral nodules production. Here,...

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Bibliographic Details
Main Authors: Rahyza I. F. Assis, Francesca Racca, Rogério S. Ferreira, Karina G. S. Ruiz, Rodrigo A. da Silva, Samuel J. H. Clokie, Malgorzata Wiench, Denise C. Andia
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Cells
Subjects:
periodontal ligament cells
osteogenesis
DNA methylation
transcriptome
epigenomics
Online Access:https://www.mdpi.com/2073-4409/11/7/1126

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https://www.mdpi.com/2073-4409/11/7/1126

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