Decreased TMIGD1 aggravates colitis and intestinal barrier dysfunction via the BANF1-NF-κB pathway in Crohn’s disease

Decreased TMIGD1 aggravates colitis and intestinal barrier dysfunction via the BANF1-NF-κB pathway in Crohn’s disease

Abstract Background Disrupted intestinal epithelial barrier is one of the major causes of Crohn’s disease (CD). Novel molecular targets for intestinal epithelial barrier are essential to treatment of CD. Transmembrane and immunoglobulin domain-containing protein 1 (TMIGD1) is an adhesion molecule th...

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Bibliographic Details
Main Authors: Longyuan Zhou, Liguo Zhu, Xiaomin Wu, Shixian Hu, Shenghong Zhang, Min Ning, Jun Yu, Minhu Chen
Format: Article
Language:English
Published: BMC 2023-08-01
Series:BMC Medicine
Subjects:
Crohn’s disease
TMIGD1
BANF1
Intestinal epithelial barrier
NF-κB pathway
Online Access:https://doi.org/10.1186/s12916-023-02989-2

Internet

https://doi.org/10.1186/s12916-023-02989-2

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