The role of ERK-1 and ERK-2 gene polymorphisms in PCOS pathogenesis

The role of ERK-1 and ERK-2 gene polymorphisms in PCOS pathogenesis

Abstract Background Ovulation is regulated by extracellular signal-regulated kinase-1 (ERK-1) and ERK-2 signaling mechanisms, and ERK-1/2 kinases modulates the function of most of the LH-regulated genes. Defective ERK kinase signaling that is secondary to a genetic problem contributes to both ovulat...

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Bibliographic Details
Main Authors: Gurhan Guney, Mine Islimye Taşkın, Nazli Sener, Ezgi Tolu, Yavuz Dodurga, Levent Elmas, Orkun Cetin, Cengiz Sarigul
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Reproductive Biology and Endocrinology
Subjects:
PCOS
ERK-1
ERK-2
Genetic polymorphism
Online Access:https://doi.org/10.1186/s12958-022-00967-6

Internet

https://doi.org/10.1186/s12958-022-00967-6

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