Active constituent of Polygala tenuifolia attenuates cognitive deficits by rescuing hippocampal neurogenesis in APP/PS1 transgenic mice

Active constituent of Polygala tenuifolia attenuates cognitive deficits by rescuing hippocampal neurogenesis in APP/PS1 transgenic mice

Abstract Background Alzheimer’s disease (AD) is the most common dementia worldwide, and there is still no satisfactory drug or therapeutic strategy. Polygala tenuifolia is a traditional Chinese medicine with multiple neuroprotective effects. In present study, we investigated the effects of three act...

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Bibliographic Details
Main Authors: Xiao-feng Wang, Hong-he Xiao, Yu-tong Wu, Liang Kong, Ji-cong Chen, Jing-xian Yang, Xiao-le Hu
Format: Article
Language:English
Published: BMC 2021-10-01
Series:BMC Complementary Medicine and Therapies
Subjects:
Alzheimer disease
Neurogenesis
Neural stem cells
Polygala tenuifolia
3,6′-disinapoyl sucrose
Online Access:https://doi.org/10.1186/s12906-021-03437-5

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