Pre-40S ribosome biogenesis factor Tsr1 is an inactive structural mimic of translational GTPases
Tsr1 is an essential ribosome biogenesis factor that has known similarity to GTPases. Here, the authors report the Tsr1 crystal structure and show that it is similar to GTPases but that active site residues are not conserved; modelling of the structure into the pre-40S maps allows inferences on ribo...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms11789 |
| _version_ | 1831706379524505600 |
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| author | Urszula M. McCaughan Uma Jayachandran Vadim Shchepachev Zhuo Angel Chen Juri Rappsilber David Tollervey Atlanta G. Cook |
| author_facet | Urszula M. McCaughan Uma Jayachandran Vadim Shchepachev Zhuo Angel Chen Juri Rappsilber David Tollervey Atlanta G. Cook |
| author_sort | Urszula M. McCaughan |
| collection | DOAJ |
| description | Tsr1 is an essential ribosome biogenesis factor that has known similarity to GTPases. Here, the authors report the Tsr1 crystal structure and show that it is similar to GTPases but that active site residues are not conserved; modelling of the structure into the pre-40S maps allows inferences on ribosomal maturation to be drawn. |
| first_indexed | 2024-12-20T16:38:25Z |
| format | Article |
| id | doaj.art-71478f9399644dc58a00d02238d1c896 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T16:38:25Z |
| publishDate | 2016-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-71478f9399644dc58a00d02238d1c8962022-12-21T19:33:05ZengNature PortfolioNature Communications2041-17232016-06-01711810.1038/ncomms11789Pre-40S ribosome biogenesis factor Tsr1 is an inactive structural mimic of translational GTPasesUrszula M. McCaughan0Uma Jayachandran1Vadim Shchepachev2Zhuo Angel Chen3Juri Rappsilber4David Tollervey5Atlanta G. Cook6Wellcome Trust Centre for Cell Biology, University of EdinburghWellcome Trust Centre for Cell Biology, University of EdinburghWellcome Trust Centre for Cell Biology, University of EdinburghWellcome Trust Centre for Cell Biology, University of EdinburghWellcome Trust Centre for Cell Biology, University of EdinburghWellcome Trust Centre for Cell Biology, University of EdinburghWellcome Trust Centre for Cell Biology, University of EdinburghTsr1 is an essential ribosome biogenesis factor that has known similarity to GTPases. Here, the authors report the Tsr1 crystal structure and show that it is similar to GTPases but that active site residues are not conserved; modelling of the structure into the pre-40S maps allows inferences on ribosomal maturation to be drawn.https://doi.org/10.1038/ncomms11789 |
| spellingShingle | Urszula M. McCaughan Uma Jayachandran Vadim Shchepachev Zhuo Angel Chen Juri Rappsilber David Tollervey Atlanta G. Cook Pre-40S ribosome biogenesis factor Tsr1 is an inactive structural mimic of translational GTPases Nature Communications |
| title | Pre-40S ribosome biogenesis factor Tsr1 is an inactive structural mimic of translational GTPases |
| title_full | Pre-40S ribosome biogenesis factor Tsr1 is an inactive structural mimic of translational GTPases |
| title_fullStr | Pre-40S ribosome biogenesis factor Tsr1 is an inactive structural mimic of translational GTPases |
| title_full_unstemmed | Pre-40S ribosome biogenesis factor Tsr1 is an inactive structural mimic of translational GTPases |
| title_short | Pre-40S ribosome biogenesis factor Tsr1 is an inactive structural mimic of translational GTPases |
| title_sort | pre 40s ribosome biogenesis factor tsr1 is an inactive structural mimic of translational gtpases |
| url | https://doi.org/10.1038/ncomms11789 |
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