Integrative Genomic Analyses of Patient-Matched Intracranial and Extracranial Metastases Reveal a Novel Brain-Specific Landscape of Genetic Variants in Driver Genes of Malignant Melanoma

Integrative Genomic Analyses of Patient-Matched Intracranial and Extracranial Metastases Reveal a Novel Brain-Specific Landscape of Genetic Variants in Driver Genes of Malignant Melanoma

Background: Development of brain metastases in advanced melanoma patients is a frequent event that limits patients’ quality of life and survival. Despite recent insights into melanoma genetics, systematic analyses of genetic alterations in melanoma brain metastasis formation are lacking. Moreover, w...

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Bibliographic Details
Main Authors: Renáta Váraljai, Susanne Horn, Antje Sucker, Daniela Piercianek, Verena Schmitt, Alexander Carpinteiro, Katrin Anne Becker, Julia Reifenberger, Alexander Roesch, Jörg Felsberg, Guido Reifenberger, Ulrich Sure, Dirk Schadendorf, Iris Helfrich
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cancers
Subjects:
melanoma brain metastases
matched-pair analyses
single nucleotide polymorphism
mutational load
oncogenes
Online Access:https://www.mdpi.com/2072-6694/13/4/731

Internet

https://www.mdpi.com/2072-6694/13/4/731

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