A tRNA modification balances carbon and nitrogen metabolism by regulating phosphate homeostasis

A tRNA modification balances carbon and nitrogen metabolism by regulating phosphate homeostasis

Cells must appropriately sense and integrate multiple metabolic resources to commit to proliferation. Here, we report that S. cerevisiae cells regulate carbon and nitrogen metabolic homeostasis through tRNA U34-thiolation. Despite amino acid sufficiency, tRNA-thiolation deficient cells appear amino...

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Bibliographic Details
Main Authors: Ritu Gupta, Adhish S Walvekar, Shun Liang, Zeenat Rashida, Premal Shah, Sunil Laxman
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-07-01
Series:eLife
Subjects:
metabolism
phosphate
methionine
tRNA modification
trehalose
cell cycle
Online Access:https://elifesciences.org/articles/44795

Internet

https://elifesciences.org/articles/44795

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