An allosteric transport mechanism for the AcrAB-TolC multidrug efflux pump

An allosteric transport mechanism for the AcrAB-TolC multidrug efflux pump

Bacterial efflux pumps confer multidrug resistance by transporting diverse antibiotics from the cell. In Gram-negative bacteria, some of these pumps form multi-protein assemblies that span the cell envelope. Here, we report the near-atomic resolution cryoEM structures of the Escherichia coli AcrAB-T...

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Bibliographic Details
Main Authors: Zhao Wang, Guizhen Fan, Corey F Hryc, James N Blaza, Irina I Serysheva, Michael F Schmid, Wah Chiu, Ben F Luisi, Dijun Du
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-03-01
Series:eLife
Subjects:
drug efflux
tripartite assembly
TolC
Carb
AcrA
AcrZ
Online Access:https://elifesciences.org/articles/24905

Internet

https://elifesciences.org/articles/24905

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