A Mediation Approach to Discovering Causal Relationships between the Metabolome and DNA Methylation in Type 1 Diabetes

A Mediation Approach to Discovering Causal Relationships between the Metabolome and DNA Methylation in Type 1 Diabetes

Environmental factors including viruses, diet, and the metabolome have been linked with the appearance of islet autoimmunity (IA) that precedes development of type 1 diabetes (T1D). We measured global DNA methylation (DNAm) and untargeted metabolomics prior to IA and at the time of seroconversion to...

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Bibliographic Details
Main Authors: Tim Vigers, Lauren A. Vanderlinden, Randi K. Johnson, Patrick M. Carry, Ivana Yang, Brian C. DeFelice, Alexander M. Kaizer, Laura Pyle, Marian Rewers, Oliver Fiehn, Jill M. Norris, Katerina Kechris
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Metabolites
Subjects:
DNA methylation
metabolomics
type 1 diabetes
Online Access:https://www.mdpi.com/2218-1989/11/8/542

Internet

https://www.mdpi.com/2218-1989/11/8/542

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