Prenatal Ethanol Exposure Misregulates Genes Involved in Iron Homeostasis Promoting a Maladaptation of Iron Dependent Hippocampal Synaptic Transmission and Plasticity

Prenatal Ethanol Exposure Misregulates Genes Involved in Iron Homeostasis Promoting a Maladaptation of Iron Dependent Hippocampal Synaptic Transmission and Plasticity

Prenatal ethanol exposure (PAE) induces behavioral maladptations in offspring, including a deficit in memory formation which is part of the umbrella sign of fetal alcohol spectrum disorder. Clinical and preclinical studies have shown that iron depletion exacerbates cognitive problems in offspring ex...

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Bibliographic Details
Main Authors: Erwin De La Fuente-Ortega, Wladimir Plaza-Briceño, Sofía Vargas-Robert, Paola Haeger
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Pharmacology
Subjects:
fetal alcohol syndrome
iron homeostasis
glutamatergic transmission
long term potentiation
adolescence
fetal brain programming
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01312/full

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https://www.frontiersin.org/article/10.3389/fphar.2019.01312/full

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