Age-dependent neuroplasticity mechanisms in Alzheimer Tg2576 mice following modulation of brain amyloid-β levels.

Age-dependent neuroplasticity mechanisms in Alzheimer Tg2576 mice following modulation of brain amyloid-β levels.

The objective of this study was to investigate the effects of modulating brain amyloid-β (Aβ) levels at different stages of amyloid pathology on synaptic function, inflammatory cell changes and hippocampal neurogenesis, i.e. processes perturbed in Alzheimer's disease (AD). Young (4- to 6-month-...

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Bibliographic Details
Main Authors: Anna M Lilja, Jennie Röjdner, Tamanna Mustafiz, Carina M Thomé, Elisa Storelli, Daniel Gonzalez, Christina Unger-Lithner, Nigel H Greig, Agneta Nordberg, Amelia Marutle
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3598857?pdf=render

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http://europepmc.org/articles/PMC3598857?pdf=render

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