Polyester Nanocapsules for Intravenous Delivery of Artemether: Formulation Development, Antimalarial Efficacy, and Cardioprotective Effects In Vivo

Polyester Nanocapsules for Intravenous Delivery of Artemether: Formulation Development, Antimalarial Efficacy, and Cardioprotective Effects In Vivo

Artemether (ATM) is an effective antimalarial drug that also has a short half-life in the blood. Furthermore, ATM is also cardiotoxic and is associated with pro-arrhythmogenic risks. We aimed to develop a delivery system enabling the prolonged release of ATM into the blood coupled with reduced cardi...

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Bibliographic Details
Main Authors: Alessandra Teixeira Vidal-Diniz, Homero Nogueira Guimarães, Giani Martins Garcia, Érika Martins Braga, Sylvain Richard, Andrea Grabe-Guimarães, Vanessa Carla Furtado Mosqueira
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Polymers
Subjects:
nanocapsules
QT interval
cardiotoxicity
artemether
malaria
self-assembled polymers
Online Access:https://www.mdpi.com/2073-4360/14/24/5503

Internet

https://www.mdpi.com/2073-4360/14/24/5503

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