HBXIP blocks myosin-IIA assembly by phosphorylating and interacting with NMHC-IIA in breast cancer metastasis

HBXIP blocks myosin-IIA assembly by phosphorylating and interacting with NMHC-IIA in breast cancer metastasis

Tumor metastasis depends on the dynamic balance of the actomyosin cytoskeleton. As a key component of actomyosin filaments, non-muscle myosin-IIA disassembly contributes to tumor cell spreading and migration. However, its regulatory mechanism in tumor migration and invasion is poorly understood. Her...

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Bibliographic Details
Main Authors: Lu Zhang, Xiaolei Zhou, Bowen Liu, Xuhe Shi, Xianmeng Li, Feifei Xu, Xueli Fu, Xue Wang, Kai Ye, Tianzhi Jin, Huimin Sun, Qianqian Li, Weiying Zhang, Lihong Ye
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Breast cancer metastasis
Actomyosin cytoskeleton
HBXIP
Myosin-IIA
NMHC-IIA
Phosphorylation
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383522004920

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http://www.sciencedirect.com/science/article/pii/S2211383522004920

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