Sensitive inference of alignment-safe intervals from biodiverse protein sequence clusters using EMERALD

Sensitive inference of alignment-safe intervals from biodiverse protein sequence clusters using EMERALD

Abstract Sequence alignments are the foundations of life science research, but most innovation so far focuses on optimal alignments, while information derived from suboptimal solutions is ignored. We argue that one optimal alignment per pairwise sequence comparison is a reasonable approximation whe...

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Bibliographic Details
Main Authors: Andreas Grigorjew, Artur Gynter, Fernando H. C. Dias, Benjamin Buchfink, Hajk-Georg Drost, Alexandru I. Tomescu
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Genome Biology
Subjects:
Sequence alignment
Dynamic programming
Needleman-Wunsch algorithm
Protein folding
Suboptimal alignments
Online Access:https://doi.org/10.1186/s13059-023-03008-6

Internet

https://doi.org/10.1186/s13059-023-03008-6

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