Loss of Tropomodulin4 in the zebrafish mutant träge causes cytoplasmic rod formation and muscle weakness reminiscent of nemaline myopathy

Loss of Tropomodulin4 in the zebrafish mutant träge causes cytoplasmic rod formation and muscle weakness reminiscent of nemaline myopathy

Nemaline myopathy is an inherited muscle disease that is mainly diagnosed by the presence of nemaline rods in muscle biopsies. Of the nine genes associated with the disease, five encode components of striated muscle sarcomeres. In a genetic zebrafish screen, the mutant träge (trg) was isolated based...

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Bibliographic Details
Main Authors: Joachim Berger, Hakan Tarakci, Silke Berger, Mei Li, Thomas E. Hall, Anders Arner, Peter D. Currie
Format: Article
Language:English
Published: The Company of Biologists 2014-12-01
Series:Disease Models & Mechanisms
Subjects:
Myofibrillogenesis
Nemaline myopathy
Neuromuscular disorder
Sarcomere assembly
tmod
Tropomodulin
Online Access:http://dmm.biologists.org/content/7/12/1407

Internet

http://dmm.biologists.org/content/7/12/1407

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