MPTP and DSP-4 susceptibility of substantia nigra and locus coeruleus catecholaminergic neurons in mice is independent of parkin activity

MPTP and DSP-4 susceptibility of substantia nigra and locus coeruleus catecholaminergic neurons in mice is independent of parkin activity

Mutations in the parkin gene cause autosomal recessive familial Parkinson's disease (PD). Parkin-deficient mouse models fail to recapitulate nigrostriatal dopaminergic neurodegeneration as seen in PD, but produce deficits in dopaminergic neurotransmission and noradrenergic-dependent behavior. S...

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Bibliographic Details
Main Authors: Bobby Thomas, Rainer von Coelln, Allen S. Mandir, Daniel B. Trinkaus, Mohamed H. Farah, Kah Leong Lim, Noel Y. Calingasan, M. Flint Beal, Valina L. Dawson, Ted M. Dawson
Format: Article
Language:English
Published: Elsevier 2007-05-01
Series:Neurobiology of Disease
Subjects:
Parkinson's disease
Parkin
Alpha-synuclein
MPTP
DSP-4
Substantia nigra
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996106003226

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http://www.sciencedirect.com/science/article/pii/S0969996106003226

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