PYCR1 promotes the malignant progression of lung cancer through the JAK-STAT3 signaling pathway via PRODH-dependent glutamine synthesize

Background: Lung cancer is a serious threat to human life. It is of great significance to elucidate the pathogenesis of lung cancer and search for new markers. This study evaluate the clinical value of pyrroline-5-carboxylate reductase 1 (PYCR1) and explore its role and mechanisms in the malignant p...

Full description

Bibliographic Details
Main Authors: Lihong Zhang, Xinyu Zhao, Enqin Wang, Ye Yang, Liangfeng Hu, Hongkun Xu, Baojun Zhang
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Translational Oncology
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523323000530