PYCR1 promotes the malignant progression of lung cancer through the JAK-STAT3 signaling pathway via PRODH-dependent glutamine synthesize

PYCR1 promotes the malignant progression of lung cancer through the JAK-STAT3 signaling pathway via PRODH-dependent glutamine synthesize

Background: Lung cancer is a serious threat to human life. It is of great significance to elucidate the pathogenesis of lung cancer and search for new markers. This study evaluate the clinical value of pyrroline-5-carboxylate reductase 1 (PYCR1) and explore its role and mechanisms in the malignant p...

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Bibliographic Details
Main Authors: Lihong Zhang, Xinyu Zhao, Enqin Wang, Ye Yang, Liangfeng Hu, Hongkun Xu, Baojun Zhang
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Translational Oncology
Subjects:
PYCR1
JAK-STAT3
PRODH
Glutamine
PD-L1
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523323000530

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