Generation and Functional Analysis of Defective Viral Genomes during SARS-CoV-2 Infection

Generation and Functional Analysis of Defective Viral Genomes during SARS-CoV-2 Infection

ABSTRACT Defective viral genomes (DVGs) have been identified in many RNA viruses as a major factor influencing antiviral immune response and viral pathogenesis. However, the generation and function of DVGs in SARS-CoV-2 infection are less known. In this study, we elucidated DVG generation in SARS-Co...

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Bibliographic Details
Main Authors: Terry Zhou, Nora J. Gilliam, Sizhen Li, Simone Spandau, Raven M. Osborn, Sarah Connor, Christopher S. Anderson, Thomas J. Mariani, Juilee Thakar, Stephen Dewhurst, David H. Mathews, Liang Huang, Yan Sun
Format: Article
Language:English
Published: American Society for Microbiology 2023-06-01
Series:mBio
Subjects:
defective viral genomes
SARS-CoV-2
recombination
secondary structure
type I/III IFN responses
human epithelial cells
Online Access:https://journals.asm.org/doi/10.1128/mbio.00250-23

Internet

https://journals.asm.org/doi/10.1128/mbio.00250-23

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