Hem1 is essential for ruffled border formation in osteoclasts and efficient bone resorption

Hem1 is essential for ruffled border formation in osteoclasts and efficient bone resorption

Abstract Bone resorption is highly dependent on the dynamic rearrangement of the osteoclast actin cytoskeleton to allow formation of actin rings and a functional ruffled border. Hem1 is a hematopoietic-specific subunit of the WAVE-complex which regulates actin polymerization and is crucial for lamel...

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Bibliographic Details
Main Authors: Eugenie Werbenko, David J. J. de Gorter, Simon Kleimann, Denise Beckmann, Vanessa Waltereit-Kracke, Julia Reinhardt, Fabienne Geers, Peter Paruzel, Uwe Hansen, Thomas Pap, Theresia E. B. Stradal, Berno Dankbar
Format: Article
Language:English
Published: Nature Portfolio 2024-04-01
Series:Scientific Reports
Subjects:
Hem1
Wave
Osteoclast
Ruffled border
Online Access:https://doi.org/10.1038/s41598-024-58110-x

Internet

https://doi.org/10.1038/s41598-024-58110-x

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