Vertical sleeve gastrectomy normalizes circulating glucocorticoid levels and lowers glucocorticoid action tissue-selectively in mice

Vertical sleeve gastrectomy normalizes circulating glucocorticoid levels and lowers glucocorticoid action tissue-selectively in mice

ObjectivesGlucocorticoids produced by the adrenal cortex are essential for the maintenance of metabolic homeostasis. Glucocorticoid activation is catalysed by 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1). Excess glucocorticoids are associated with insulin resistance and hyperglycaemia. A small numb...

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Bibliographic Details
Main Authors: Elina Akalestou, Livia Lopez-Noriega, Ioannis Christakis, Ming Hu, Alexander D. Miras, Isabelle Leclerc, Guy A. Rutter
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Endocrinology
Subjects:
bariatric surgery
diabetes
adrenal glands
glucocorticoids
11β-HSD1
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.1020576/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2022.1020576/full

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