Impact of Aging, Cytomegalovirus Infection, and Long-Term Treatment for Human Immunodeficiency Virus on CD8+ T-Cell Subsets

Impact of Aging, Cytomegalovirus Infection, and Long-Term Treatment for Human Immunodeficiency Virus on CD8+ T-Cell Subsets

Both healthy aging and human immunodeficiency virus (HIV) infection lead to a progressive decline in naive CD8+ T-cell numbers and expansion of the CD8+ T-cell memory and effector compartments. HIV infection is therefore often considered a condition of premature aging. Total CD8+ T-cell numbers of H...

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Bibliographic Details
Main Authors: Ellen Veel, Liset Westera, Rogier van Gent, Louis Bont, Sigrid Otto, Bram Ruijsink, Huib H. Rabouw, Tania Mudrikova, Annemarie Wensing, Andy I. M. Hoepelman, José A. M. Borghans, Kiki Tesselaar
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Immunology
Subjects:
healthy aging
cytomegalovirus
human immunodeficiency virus infection
combination antiretroviral treatment
CD8+ T-cells
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00572/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00572/full

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