Activation of adult mammalian retinal stem cells in vivo via antagonism of BMP and sFRP2

Abstract Background The adult mammalian retina does not have the capacity to regenerate cells lost due to damage or disease. Therefore, retinal injuries and blinding diseases result in irreversible vision loss. However, retinal stem cells (RSCs), which participate in retinogenesis during development...

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Bibliographic Details
Main Authors: Kenneth N. Grisé, Brenda L. K. Coles, Nelson X. Bautista, Derek van der Kooy
Format: Article
Language:English
Published: BMC 2021-10-01
Series:Stem Cell Research & Therapy
Subjects:
Online Access:https://doi.org/10.1186/s13287-021-02630-0