Unmixing for ultra-high-plex fluorescence imaging

Writing in Nature communications, Seo and collaborators presented PICASSO as a method to achieve 15-color imaging of spatially overlapping proteins using no reference emission spectra in a single staining and imaging round. This accessible tool has the potential to be applied to diverse applications...

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Bibliographic Details
Main Authors: Archibald Enninful, Alev Baysoy, Rong Fan
Format: Article
Language:English
Published: Nature Portfolio 2022-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-31110-z