DNA methylation reprogramming of human cancer cells by expression of a plant 5-methylcytosine DNA glycosylase

DNA methylation reprogramming of human cancer cells by expression of a plant 5-methylcytosine DNA glycosylase

Patterns of DNA methylation, an important epigenetic modification involved in gene silencing and development, are disrupted in cancer cells. Understanding the functional significance of aberrant methylation in tumors remains challenging, due in part to the lack of suitable tools to actively modify m...

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Bibliographic Details
Main Authors: Teresa Morales-Ruiz, María Victoria García-Ortiz, Iván Devesa-Guerra, Laura Raya-Ruiz, Juan R. Tejedor, Gustavo F. Bayón, Marta I. Sierra, Mario F. Fraga, Rafael R. Ariza, Teresa Roldán-Arjona
Format: Article
Language:English
Published: Taylor & Francis Group 2018-01-01
Series:Epigenetics
Subjects:
epigenetics
colon cancer
dna methylation
dna demethylation
base excision repair
Online Access:http://dx.doi.org/10.1080/15592294.2017.1414128

Internet

http://dx.doi.org/10.1080/15592294.2017.1414128

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