Fusobacterium nucleatum Infection in Colorectal Cancer: Linking Inflammation, DNA Mismatch Repair and Genetic and Epigenetic Alterations

Fusobacterium nucleatum Infection in Colorectal Cancer: Linking Inflammation, DNA Mismatch Repair and Genetic and Epigenetic Alterations

It has been recently reported that the population of Fusobacterium, particularly Fusobacteriumnucleatum (Fn), is overrepresented in colorectal cancers (CRCs) and adenomas. The promoting effects of Fn infection on adenoma and/or carcinoma formation have been shown in ApcMin/+mice. Characteristics of...

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Bibliographic Details
Main Authors: Minoru Koi, Yoshiki Okita, John M. Carethers
Format: Article
Language:English
Published: The Japan Society of Coloproctology 2018-04-01
Series:Journal of the Anus, Rectum and Colon
Subjects:
microsatellite instability-high (MSI-H)
elevated microsatellite alterations at selected tetra-nucleotide repeats (EMAST)
colorectal cancer (CRC)
mismatch repair (MMR)
Fusobacterium nucleatum
CpG island methylator phenotype (CIMP)
Online Access:https://www.jstage.jst.go.jp/article/jarc/2/2/2_2017-055/_pdf/-char/en

Internet

https://www.jstage.jst.go.jp/article/jarc/2/2/2_2017-055/_pdf/-char/en

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