Structural and functional characterization of a single-chain form of the recognition domain of complement protein C1q

Structural and functional characterization of a single-chain form of the recognition domain of complement protein C1q

Complement C1q is a soluble pattern recognition molecule comprising six heterotrimeric subunits assembled from three polypeptide chains (A, B, and C). Each heterotrimer forms a collagen-like stem prolonged by a globular recognition domain. These recognition domains sense a wide variety of ligands, i...

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Bibliographic Details
Main Authors: Christophe eMoreau, Isabelle eBally, Anne eChouquet, Barbara eBottazzi, Berhane eGhebrehiwet, Christine eGaboriaud, Nicole eThielens
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-03-01
Series:Frontiers in Immunology
Subjects:
Protein Engineering
Surface Plasmon Resonance
c1q
complement
X-ray crystallography
Innate immune recognition
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00079/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00079/full

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