Optimized intramuscular immunization with VSV-vectored spike protein triggers a superior immune response to SARS-CoV-2

Optimized intramuscular immunization with VSV-vectored spike protein triggers a superior immune response to SARS-CoV-2

Abstract Immunization with vesicular stomatitis virus (VSV)-vectored COVID-19 vaccine candidates expressing the SARS-CoV-2 spike protein in place of the VSV glycoprotein relies implicitly on expression of the ACE2 receptor at the muscular injection site. Here, we report that such a viral vector vacc...

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Bibliographic Details
Main Authors: Adriano Taddeo, Inês Berenguer Veiga, Christelle Devisme, Renate Boss, Philippe Plattet, Sebastian Weigang, Georg Kochs, Volker Thiel, Charaf Benarafa, Gert Zimmer
Format: Article
Language:English
Published: Nature Portfolio 2022-07-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-022-00508-7

Internet

https://doi.org/10.1038/s41541-022-00508-7

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