Successful reduction of high-sustained anti-idursulfase antibody titers by immune modulation therapy in a patient with severe mucopolysaccharidosis type II

Successful reduction of high-sustained anti-idursulfase antibody titers by immune modulation therapy in a patient with severe mucopolysaccharidosis type II

We report on a 6 year old boy with severe MPS II undergoing immune modulation therapy due to high IgG antibody titers to IV idursulfase and no significant decline in urinary GAG levels since initiating enzyme replacement therapy. He has complete deficiency of iduronate-2-sulfatase activity due to a...

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Bibliographic Details
Main Authors: Katherine H. Kim, Yoav H. Messinger, Barbara K. Burton
Format: Article
Language:English
Published: Elsevier 2015-03-01
Series:Molecular Genetics and Metabolism Reports
Subjects:
MPS II
Immune modulation
Anti-idursulfase antibody titer
Enzyme replacement therapy
Treatment
Online Access:http://www.sciencedirect.com/science/article/pii/S2214426914000779

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http://www.sciencedirect.com/science/article/pii/S2214426914000779

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