A CRISPR-Cas12a-based platform for ultrasensitive rapid highly specific detection of Mycobacterium tuberculosis in clinical application

A CRISPR-Cas12a-based platform for ultrasensitive rapid highly specific detection of Mycobacterium tuberculosis in clinical application

Tuberculosis, caused by Mycobacterium tuberculosis (MTB), is the second leading cause of death after COVID-19 pandemic. Here, we coupled multiple cross displacement amplification (MCDA) technique with CRISPR-Cas12a-based biosensing system to design a novel detection platform for tuberculosis diagnos...

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Bibliographic Details
Main Authors: Nan Jia, Chaohong Wang, Xiaming Liu, Xiaolan Huang, Fei Xiao, Jin Fu, Chunrong Sun, Zheng Xu, Guirong Wang, Juan Zhou, Yi Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Mycobacterium tuberculosis
multiple cross displacement amplification
CRISPR
Cas12a
tuberculosis
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2023.1192134/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2023.1192134/full

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