Molecular and spatial heterogeneity of microglia in Rasmussen encephalitis

Molecular and spatial heterogeneity of microglia in Rasmussen encephalitis

Abstract Rasmussen encephalitis (RE) is a rare childhood neurological disease characterized by progressive unilateral loss of function, hemispheric atrophy and drug-resistant epilepsy. Affected brain tissue shows signs of infiltrating cytotoxic T-cells, microglial activation, and neuronal death, imp...

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Bibliographic Details
Main Authors: Jesse J. Westfall, Wesley N. Schwind, Sahibjot Sran, Jason B. Navarro, Jeffrey Leonard, Jonathan A. Pindrik, Christopher R. Pierson, Daniel R. Boué, Daniel C. Koboldt, Adam P. Ostendorf, Richard K. Wilson, Elaine R. Mardis, Katherine E. Miller, Tracy A. Bedrosian
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Acta Neuropathologica Communications
Subjects:
Encephalitis
Microglial nodules
Epilepsy
Inflammation
Spatial proteomics
Single nucleus RNA-seq
Online Access:https://doi.org/10.1186/s40478-022-01472-y

Internet

https://doi.org/10.1186/s40478-022-01472-y

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