Regulatory T cells modulate DNA vaccine immunogenicity at early time via functional CD4+T cells and antigen duration

Regulatory T cells modulate DNA vaccine immunogenicity at early time via functional CD4+T cells and antigen duration

The development of an effective vaccine against HIV has proved to be difficult. Many factors including natural regulatory T cells (Treg cells), can dampen the CD8 T cell immunogenicity. In this study, we aimed to understand how Treg cells control CD8+ T cell immune responses during DNA prime-boost i...

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Bibliographic Details
Main Authors: Lizeng eQin, Guosheng eJiang, Jinxiang eHan, Norman L Letvin
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-09-01
Series:Frontiers in Immunology
Subjects:
antigen
DNA vaccine
Immunogenicity
Mice.
Regulatory T cells (Treg cell)
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00510/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00510/full

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