Deletion of Neuronal CuZnSOD Accelerates Age-Associated Muscle Mitochondria and Calcium Handling Dysfunction That Is Independent of Denervation and Precedes Sarcopenia

Deletion of Neuronal CuZnSOD Accelerates Age-Associated Muscle Mitochondria and Calcium Handling Dysfunction That Is Independent of Denervation and Precedes Sarcopenia

Skeletal muscle suffers atrophy and weakness with aging. Denervation, oxidative stress, and mitochondrial dysfunction are all proposed as contributors to age-associated muscle loss, but connections between these factors have not been established. We examined contractility, mitochondrial function, an...

Full description

Bibliographic Details
Main Authors: Yu Su, Dennis R. Claflin, Meixiang Huang, Carol S. Davis, Peter C. D. Macpherson, Arlan Richardson, Holly Van Remmen, Susan V. Brooks
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:International Journal of Molecular Sciences
Subjects:
sarcopenia
oxidative stress
denervation
NADH
calcium
Online Access:https://www.mdpi.com/1422-0067/22/19/10735

Internet

https://www.mdpi.com/1422-0067/22/19/10735

Similar Items