MarZIC: A Marginal Mediation Model for Zero-Inflated Compositional Mediators with Applications to Microbiome Data

MarZIC: A Marginal Mediation Model for Zero-Inflated Compositional Mediators with Applications to Microbiome Data

Background: The human microbiome can contribute to pathogeneses of many complex diseases by mediating disease-leading causal pathways. However, standard mediation analysis methods are not adequate to analyze the microbiome as a mediator due to the excessive number of zero-valued sequencing reads in...

Full description

Bibliographic Details
Main Authors: Quran Wu, James O’Malley, Susmita Datta, Raad Z. Gharaibeh, Christian Jobin, Margaret R. Karagas, Modupe O. Coker, Anne G. Hoen, Brock C. Christensen, Juliette C. Madan, Zhigang Li
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Genes
Subjects:
mediation
microbiome
relative abundance
zero-inflated composition
sparse data
Online Access:https://www.mdpi.com/2073-4425/13/6/1049

Internet

https://www.mdpi.com/2073-4425/13/6/1049

Similar Items