CRIF1 deficiency induces p66shc-mediated oxidative stress and endothelial activation.

CRIF1 deficiency induces p66shc-mediated oxidative stress and endothelial activation.

Mitochondrial dysfunction has been implicated in the pathophysiology of various cardiovascular diseases. CRIF1 is a protein present in the mitochondria associated with large mitoribosomal subunits, and CRIF1 knockdown induces mitochondrial dysfunction and promotes ROS production. p66shc is a redox e...

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Bibliographic Details
Main Authors: Harsha Nagar, Saet-byel Jung, Sun Kwan Kwon, Jung-Bum Park, Minho Shong, Hee-Jung Song, Byeong Hwa Jeon, Kaikobad Irani, Cuk-Seong Kim
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4048193?pdf=render

Internet

http://europepmc.org/articles/PMC4048193?pdf=render

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