CRIF1 deficiency induces p66shc-mediated oxidative stress and endothelial activation.

CRIF1 deficiency induces p66shc-mediated oxidative stress and endothelial activation.

Mitochondrial dysfunction has been implicated in the pathophysiology of various cardiovascular diseases. CRIF1 is a protein present in the mitochondria associated with large mitoribosomal subunits, and CRIF1 knockdown induces mitochondrial dysfunction and promotes ROS production. p66shc is a redox e...

Full description

Bibliographic Details
Main Authors:	Harsha Nagar, Saet-byel Jung, Sun Kwan Kwon, Jung-Bum Park, Minho Shong, Hee-Jung Song, Byeong Hwa Jeon, Kaikobad Irani, Cuk-Seong Kim
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2014-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC4048193?pdf=render

Similar Items

CRIF1 deficiency suppresses endothelial cell migration via upregulation of RhoGDI2.
by: Harsha Nagar, et al.
Published: (2021-01-01)

CRIF1 Deficiency Increased Homocysteine Production by Disrupting Dihydrofolate Reductase Expression in Vascular Endothelial Cells
by: Ikjun Lee, et al.
Published: (2021-10-01)

Rg3-enriched Korean Red Ginseng enhances blood pressure stability in spontaneously hypertensive rats
by: Harsha Nagar, et al.
Published: (2016-09-01)

SIRT1 Activation Attenuates the Cardiac Dysfunction Induced by Endothelial Cell-Specific Deletion of CRIF1
by: Shuyu Piao, et al.
Published: (2021-01-01)

Rg3-enriched Korean Red Ginseng improves vascular function in spontaneously hypertensive rats
by: Jung-Bum Park, et al.
Published: (2014-10-01)

Redox factor-1 activates endothelial SIRTUIN1 through reduction of conserved cysteine sulfhydryls in its deacetylase domain.
by: Saet-Byel Jung, et al.
Published: (2013-01-01)

CR6 interacting factor 1 deficiency promotes endothelial inflammation by SIRT1 downregulation.
by: Shuyu Piao, et al.
Published: (2018-01-01)

Crif1 deficiency reduces adipose OXPHOS capacity and triggers inflammation and insulin resistance in mice.
by: Min Jeong Ryu, et al.
Published: (2013-01-01)

Cellular and Intercellular Homeostasis in Adipose Tissue with Mitochondria-Specific Stress
by: Min Jeong Choi, et al.
Published: (2021-02-01)

CRIF1 siRNA-Encapsulated PLGA Nanoparticles Suppress Tumor Growth in MCF-7 Human Breast Cancer Cells
by: Shuyu Piao, et al.
Published: (2023-04-01)

p66Shc in Cardiovascular Pathology
by: Landon Haslem, et al.
Published: (2022-06-01)

Role of p66shc in skeletal muscle function
by: Veronica Granatiero, et al.
Published: (2017-07-01)

miR204 potentially promotes non-alcoholic fatty liver disease by inhibition of cpt1a in mouse hepatocytes
by: Seonhee Kim, et al.
Published: (2022-09-01)

Human SHC‐transforming protein 1 and its isoforms p66shc: A novel marker for prediabetes
by: Herbert F Jelinek, et al.
Published: (2021-10-01)

Correction to: P66Shc expression in diabetic rat retina
by: Ming-Hui Zhao, et al.
Published: (2019-03-01)

P66Shc (Shc1) Zebrafish Mutant Line as a Platform for Testing Decreased Reactive Oxygen Species in Pathology
by: Landon Haslem, et al.
Published: (2022-11-01)

Prooxidant properties of p66shc are mediated by mitochondria in human cells.
by: Evgeny R Galimov, et al.
Published: (2014-01-01)

VDR alleviates endothelial cell injury in arteriovenous fistula through inhibition of P66Shc-mediated mitochondrial ROS
by: Ya-chun Han, et al.
Published: (2023-07-01)

p66shc siRNA Nanoparticles Ameliorate Chondrocytic Mitochondrial Dysfunction in Osteoarthritis
by: Shin HJ, et al.
Published: (2020-04-01)

p66shc siRNA-Encapsulated PLGA Nanoparticles Ameliorate Neuropathic Pain Following Spinal Nerve Ligation
by: Nara Shin, et al.
Published: (2020-04-01)

The p66<sup>Shc</sup> Redox Protein and the Emerging Complications of Diabetes
by: Giuseppina Biondi, et al.
Published: (2023-12-01)

Lower p66Shc promoter methylation in subjects with chronic renal failure.
by: Radhia Hamdi, et al.
Published: (2021-01-01)

Effect of Ulinastatin on Syndecan-2-Mediated Vascular Damage in IDH2-Deficient Endothelial Cells
by: Su-jeong Choi, et al.
Published: (2022-01-01)

Dual role of endothelial nitric oxide synthase in oxidized LDL-induced, p66Shc-mediated oxidative stress in cultured human endothelial cells.
by: Yi Shi, et al.
Published: (2014-01-01)

Multifunctions of CRIF1 in cancers and mitochondrial dysfunction
by: Yangzhou Jiang, et al.
Published: (2022-10-01)

Deficiency of Crif1 in hair follicle stem cells retards hair growth cycle in adult mice.
by: Jung-Min Shin, et al.
Published: (2020-01-01)

Lack of Contribution of p66shc to Pressure Overload-Induced Right Heart Hypertrophy
by: Christine Hirschhäuser, et al.
Published: (2020-12-01)

The Adaptor Protein p66Shc Inhibits mTOR-Dependent Anabolic Metabolism
by: Lamming, Dudley W., et al.
Published: (2015)

Regulation of Selective B Cell Autophagy by the Pro-oxidant Adaptor p66SHC
by: Anna Onnis, et al.
Published: (2020-03-01)

p66ShcA functions as a contextual promoter of breast cancer metastasis
by: Kyle Lewis, et al.
Published: (2020-01-01)

Suppression of p66Shc prevents hyperandrogenism-induced ovarian oxidative stress and fibrosis
by: Daojuan Wang, et al.
Published: (2020-02-01)

The tumor suppressive effect and apoptotic mechanism of TRAIL gene‐containing recombinant NDV in TRAIL‐resistant colorectal cancer HT‐29 cells and TRAIL‐nonresistant HCT116 cells, with each cell bearing a mouse model
by: Bo‐Kyoung Jung, et al.
Published: (2023-10-01)

Cardiomyocyte specific deletion of Crif1 causes mitochondrial cardiomyopathy in mice.
by: Juhee Shin, et al.
Published: (2013-01-01)

Increased p66Shc in the inner ear of D-galactose-induced aging mice with accumulation of mitochondrial DNA 3873-bp deletion: p66Shc and mtDNA damage in the inner ear during aging.
by: Lisa Wu, et al.
Published: (2012-01-01)

Corrigendum: Multifunctions of CRIF1 in cancers and mitochondrial dysfunction
by: Yangzhou Jiang, et al.
Published: (2023-08-01)

The oxidoreductase p66Shc acts as tumor suppressor in BRAFV600E‐transformed cells
by: Tobias Furlan, et al.
Published: (2018-06-01)

The p66(Shc) adaptor protein controls oxidative stress response in early bovine embryos.
by: Dean H Betts, et al.
Published: (2014-01-01)

p66Shc gene expression in peripheral blood mononuclear cells and progression of diabetic complications
by: Gian Paolo Fadini, et al.
Published: (2018-01-01)

Smoking p66Shc knocked out mice develop respiratory bronchiolitis with fibrosis but not emphysema.
by: Benedetta Lunghi, et al.
Published: (2015-01-01)

IDH2 Deficiency Promotes Endothelial Senescence by Eliciting miR-34b/c-Mediated Suppression of Mitophagy and Increased ROS Production
by: Ikjun Lee, et al.
Published: (2023-02-01)