Novel Dual AChE and ROCK2 Inhibitor Induces Neurogenesis via PTEN/AKT Pathway in Alzheimer’s Disease Model

Novel Dual AChE and ROCK2 Inhibitor Induces Neurogenesis via PTEN/AKT Pathway in Alzheimer’s Disease Model

Alzheimer’s disease (AD) is a progressive and complex neurodegenerative disease. Acetylcholinesterase inhibitors (AChEIs) are a major class of drugs used in AD therapy. ROCK2, another promising target for AD, has been associated with the induction of neurogenesis via PTEN/AKT. This study aimed to ch...

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Bibliographic Details
Main Authors: Natália Chermont dos Santos Moreira, Elvira Regina Tamarozzi, Jessica Ellen Barbosa de Freitas Lima, Larissa de Oliveira Piassi, Ivone Carvalho, Geraldo Aleixo Passos, Elza Tiemi Sakamoto-Hojo
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:International Journal of Molecular Sciences
Subjects:
neurodifferentiation
neurite outgrowth
molecular docking
multi-target
cholinesterase activity
Online Access:https://www.mdpi.com/1422-0067/23/23/14788

Internet

https://www.mdpi.com/1422-0067/23/23/14788

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