Optimized high‐fidelity 3DPCR to assess potential mitochondrial targeting by activation‐induced cytidine deaminase

Optimized high‐fidelity 3DPCR to assess potential mitochondrial targeting by activation‐induced cytidine deaminase

Activation‐induced cytidine deaminase (AID) initiates somatic hypermutation and class switch recombination of immunoglobulin genes in B cells, whereas off‐targeted AID activity contributes to oncogenic mutations and chromosomal translocations associated with B cell malignancies. Paradoxically, only...

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Bibliographic Details
Main Authors: Haiyan Wu, Kaili Zhang, Yue Chen, Jinfeng Li, Matthew P. Strout, Xiwen Gu
Format: Article
Language:English
Published: Wiley 2020-09-01
Series:FEBS Open Bio
Subjects:
3DPCR
activation‐induced cytidine deaminase
mitochondria
mtDNA
Online Access:https://doi.org/10.1002/2211-5463.12927

Internet

https://doi.org/10.1002/2211-5463.12927

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