Molecular and cellular characterization of a zebrafish optic pathway tumor line implicates glia-derived progenitors in tumorigenesis.

Molecular and cellular characterization of a zebrafish optic pathway tumor line implicates glia-derived progenitors in tumorigenesis.

In this study we describe the molecular and cellular characterization of a zebrafish mutant that develops tumors in the optic pathway. Heterozygous Tg(flk1:RFP)is18 transgenic adults develop tumors of the retina, optic nerve and optic tract. Molecular and genetic mapping demonstrate the tumor phenot...

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Bibliographic Details
Main Authors: Staci L Solin, Ying Wang, Joshua Mauldin, Laura E Schultz, Deborah E Lincow, Pavel A Brodskiy, Crystal A Jones, Judith Syrkin-Nikolau, Jasmine M Linn, Jeffrey J Essner, Jesse M Hostetter, Elizabeth M Whitley, J Douglas Cameron, Hui-Hsien Chou, Andrew J Severin, Donald S Sakaguchi, Maura McGrail
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4259487?pdf=render

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http://europepmc.org/articles/PMC4259487?pdf=render

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