CXADR polymorphism rs6517774 modifies islet autoimmunity characteristics and exhibits sex disparity

CXADR polymorphism rs6517774 modifies islet autoimmunity characteristics and exhibits sex disparity

Enteroviral infections have been linked to the development of islet autoimmunity (IA) and type 1 diabetes (T1D), and the coxsackie and adenovirus receptor (CXADR) is one of the ligands used by adenoviruses and enteroviruses for cell internalization. Two CXADR single nucleotide polymorphisms (SNPs),...

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Bibliographic Details
Main Authors: Lucas Nygård, Milla Valta, Antti-Pekka Laine, Jorma Toppari, Mikael Knip, Riitta Veijola, Heikki Hyöty, Jorma Ilonen, Johanna Lempainen
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Genetics
Subjects:
type 1 diabetes
SNP
CXADR
islet autoimmunity
sex disparity
autoantibodies
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2023.1248701/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2023.1248701/full

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