Mitochondrial Bcl-xL promotes brain synaptogenesis by controlling non-lethal caspase activation

Mitochondrial Bcl-xL promotes brain synaptogenesis by controlling non-lethal caspase activation

Summary: Non-lethal caspase activation (NLCA) has been linked to neurodevelopmental processes. However, how neurons control NLCA remains elusive. Here, we focused on Bcl-xL, a Bcl-2 homolog regulating caspase activation through the mitochondria. We generated a mouse model, referred to as ER-xL, in w...

Full description

Bibliographic Details
Main Authors: Trang Thi Minh Nguyen, Rudy Gadet, Marine Lanfranchi, Romane A. Lahaye, Sozerko Yandiev, Olivier Lohez, Ivan Mikaelian, Lea Jabbour, Ruth Rimokh, Julien Courchet, Frédéric Saudou, Nikolay Popgeorgiev, Germain Gillet
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:iScience
Subjects:
Molecular biology
Neuroscience
Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223007514

Internet

http://www.sciencedirect.com/science/article/pii/S2589004223007514

Similar Items