6-Amino-4-aryl-7-phenyl-3-(phenylimino)-4,7-dihydro-3H-[1,2]dithiolo[3,4-b]pyridine-5-carboxamides: Synthesis, Biological Activity, Quantum Chemical Studies and In Silico Docking Studies

6-Amino-4-aryl-7-phenyl-3-(phenylimino)-4,7-dihydro-3H-[1,2]dithiolo[3,4-b]pyridine-5-carboxamides: Synthesis, Biological Activity, Quantum Chemical Studies and In Silico Docking Studies

New [1,2]dithiolo[3,4-b]pyridine-5-carboxamides were synthesized through the reaction of dithiomalondianilide (N,N′-diphenyldithiomalondiamide) with 3-aryl-2-cyanoacrylamides or via a three-component reaction involving aromatic aldehydes, cyanoacetamide and dithiomalondianilide in the presence of mo...

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Bibliographic Details
Main Authors: Victor V. Dotsenko, Alexander V. Bespalov, Anna E. Sinotsko, Azamat Z. Temerdashev, Vladimir K. Vasilin, Ekaterina A. Varzieva, Vladimir D. Strelkov, Nicolai A. Aksenov, Inna V. Aksenova
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:International Journal of Molecular Sciences
Subjects:
heterocyclization
Michael addition
dithiomalondiamides
dithiolo[3,4-b]pyridines
DFT calculations
reaction mechanism studies
Online Access:https://www.mdpi.com/1422-0067/25/2/769

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https://www.mdpi.com/1422-0067/25/2/769

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