Arachidonic acid drives postnatal neurogenesis and elicits a beneficial effect on prepulse inhibition, a biological trait of psychiatric illnesses.
Prepulse inhibition (PPI) is a compelling endophenotype (biological markers) for mental disorders including schizophrenia. In a previous study, we identified Fabp7, a fatty acid binding protein 7 as one of the genes controlling PPI in mice and showed that this gene was associated with schizophrenia....
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2009-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC2663848?pdf=render |
| _version_ | 1828859596789252096 |
|---|---|
| author | Motoko Maekawa Noriko Takashima Miho Matsumata Shiro Ikegami Masanori Kontani Yoshinobu Hara Hiroshi Kawashima Yuji Owada Yoshinobu Kiso Takeo Yoshikawa Kaoru Inokuchi Noriko Osumi |
| author_facet | Motoko Maekawa Noriko Takashima Miho Matsumata Shiro Ikegami Masanori Kontani Yoshinobu Hara Hiroshi Kawashima Yuji Owada Yoshinobu Kiso Takeo Yoshikawa Kaoru Inokuchi Noriko Osumi |
| author_sort | Motoko Maekawa |
| collection | DOAJ |
| description | Prepulse inhibition (PPI) is a compelling endophenotype (biological markers) for mental disorders including schizophrenia. In a previous study, we identified Fabp7, a fatty acid binding protein 7 as one of the genes controlling PPI in mice and showed that this gene was associated with schizophrenia. We also demonstrated that disrupting Fabp7 dampened hippocampal neurogenesis. In this study, we examined a link between neurogenesis and PPI using different animal models and exploring the possibility of postnatal manipulation of neurogenesis affecting PPI, since gene-deficient mice show biological disturbances from prenatal stages. In parallel, we tested the potential for dietary polyunsaturated fatty acids (PUFAs), arachidonic acid (ARA) and/or docosahexaenoic acid (DHA), to promote neurogenesis and improve PPI. PUFAs are ligands for Fabp members and are abundantly expressed in neural stem/progenitor cells in the hippocampus. Our results are: (1) an independent model animal, Pax6 (+/-) rats, exhibited PPI deficits along with impaired postnatal neurogenesis; (2) methylazoxymethanol acetate (an anti-proliferative drug) elicited decreased neurogenesis even in postnatal period, and PPI defects in young adult rats (10 weeks) when the drug was given at the juvenile stage (4-5 weeks); (3) administering ARA for 4 weeks after birth promoted neurogenesis in wild type rats; (4) raising Pax6 (+/-) pups on an ARA-containing diet enhanced neurogenesis and partially improved PPI in adult animals. These results suggest the potential benefit of ARA in ameliorating PPI deficits relevant to psychiatric disorders and suggest that the effect may be correlated with augmented postnatal neurogenesis. |
| first_indexed | 2024-12-13T02:23:00Z |
| format | Article |
| id | doaj.art-719133562ff14784bf86948432aa90e5 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T02:23:00Z |
| publishDate | 2009-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-719133562ff14784bf86948432aa90e52022-12-22T00:02:44ZengPublic Library of Science (PLoS)PLoS ONE1932-62032009-01-0144e508510.1371/journal.pone.0005085Arachidonic acid drives postnatal neurogenesis and elicits a beneficial effect on prepulse inhibition, a biological trait of psychiatric illnesses.Motoko MaekawaNoriko TakashimaMiho MatsumataShiro IkegamiMasanori KontaniYoshinobu HaraHiroshi KawashimaYuji OwadaYoshinobu KisoTakeo YoshikawaKaoru InokuchiNoriko OsumiPrepulse inhibition (PPI) is a compelling endophenotype (biological markers) for mental disorders including schizophrenia. In a previous study, we identified Fabp7, a fatty acid binding protein 7 as one of the genes controlling PPI in mice and showed that this gene was associated with schizophrenia. We also demonstrated that disrupting Fabp7 dampened hippocampal neurogenesis. In this study, we examined a link between neurogenesis and PPI using different animal models and exploring the possibility of postnatal manipulation of neurogenesis affecting PPI, since gene-deficient mice show biological disturbances from prenatal stages. In parallel, we tested the potential for dietary polyunsaturated fatty acids (PUFAs), arachidonic acid (ARA) and/or docosahexaenoic acid (DHA), to promote neurogenesis and improve PPI. PUFAs are ligands for Fabp members and are abundantly expressed in neural stem/progenitor cells in the hippocampus. Our results are: (1) an independent model animal, Pax6 (+/-) rats, exhibited PPI deficits along with impaired postnatal neurogenesis; (2) methylazoxymethanol acetate (an anti-proliferative drug) elicited decreased neurogenesis even in postnatal period, and PPI defects in young adult rats (10 weeks) when the drug was given at the juvenile stage (4-5 weeks); (3) administering ARA for 4 weeks after birth promoted neurogenesis in wild type rats; (4) raising Pax6 (+/-) pups on an ARA-containing diet enhanced neurogenesis and partially improved PPI in adult animals. These results suggest the potential benefit of ARA in ameliorating PPI deficits relevant to psychiatric disorders and suggest that the effect may be correlated with augmented postnatal neurogenesis.http://europepmc.org/articles/PMC2663848?pdf=render |
| spellingShingle | Motoko Maekawa Noriko Takashima Miho Matsumata Shiro Ikegami Masanori Kontani Yoshinobu Hara Hiroshi Kawashima Yuji Owada Yoshinobu Kiso Takeo Yoshikawa Kaoru Inokuchi Noriko Osumi Arachidonic acid drives postnatal neurogenesis and elicits a beneficial effect on prepulse inhibition, a biological trait of psychiatric illnesses. PLoS ONE |
| title | Arachidonic acid drives postnatal neurogenesis and elicits a beneficial effect on prepulse inhibition, a biological trait of psychiatric illnesses. |
| title_full | Arachidonic acid drives postnatal neurogenesis and elicits a beneficial effect on prepulse inhibition, a biological trait of psychiatric illnesses. |
| title_fullStr | Arachidonic acid drives postnatal neurogenesis and elicits a beneficial effect on prepulse inhibition, a biological trait of psychiatric illnesses. |
| title_full_unstemmed | Arachidonic acid drives postnatal neurogenesis and elicits a beneficial effect on prepulse inhibition, a biological trait of psychiatric illnesses. |
| title_short | Arachidonic acid drives postnatal neurogenesis and elicits a beneficial effect on prepulse inhibition, a biological trait of psychiatric illnesses. |
| title_sort | arachidonic acid drives postnatal neurogenesis and elicits a beneficial effect on prepulse inhibition a biological trait of psychiatric illnesses |
| url | http://europepmc.org/articles/PMC2663848?pdf=render |
| work_keys_str_mv | AT motokomaekawa arachidonicaciddrivespostnatalneurogenesisandelicitsabeneficialeffectonprepulseinhibitionabiologicaltraitofpsychiatricillnesses AT norikotakashima arachidonicaciddrivespostnatalneurogenesisandelicitsabeneficialeffectonprepulseinhibitionabiologicaltraitofpsychiatricillnesses AT mihomatsumata arachidonicaciddrivespostnatalneurogenesisandelicitsabeneficialeffectonprepulseinhibitionabiologicaltraitofpsychiatricillnesses AT shiroikegami arachidonicaciddrivespostnatalneurogenesisandelicitsabeneficialeffectonprepulseinhibitionabiologicaltraitofpsychiatricillnesses AT masanorikontani arachidonicaciddrivespostnatalneurogenesisandelicitsabeneficialeffectonprepulseinhibitionabiologicaltraitofpsychiatricillnesses AT yoshinobuhara arachidonicaciddrivespostnatalneurogenesisandelicitsabeneficialeffectonprepulseinhibitionabiologicaltraitofpsychiatricillnesses AT hiroshikawashima arachidonicaciddrivespostnatalneurogenesisandelicitsabeneficialeffectonprepulseinhibitionabiologicaltraitofpsychiatricillnesses AT yujiowada arachidonicaciddrivespostnatalneurogenesisandelicitsabeneficialeffectonprepulseinhibitionabiologicaltraitofpsychiatricillnesses AT yoshinobukiso arachidonicaciddrivespostnatalneurogenesisandelicitsabeneficialeffectonprepulseinhibitionabiologicaltraitofpsychiatricillnesses AT takeoyoshikawa arachidonicaciddrivespostnatalneurogenesisandelicitsabeneficialeffectonprepulseinhibitionabiologicaltraitofpsychiatricillnesses AT kaoruinokuchi arachidonicaciddrivespostnatalneurogenesisandelicitsabeneficialeffectonprepulseinhibitionabiologicaltraitofpsychiatricillnesses AT norikoosumi arachidonicaciddrivespostnatalneurogenesisandelicitsabeneficialeffectonprepulseinhibitionabiologicaltraitofpsychiatricillnesses |